Diagnosis Psyhocology of Generic Harvoni

Screening for hepatitis C.

Health and wellness officials recommend that anyone at high danger of exposure to HCV obtain a blood examination to screen for hepatitis C infection. Individuals that might wish to speak with their doctors regarding screening for hepatitis C include:.

Any person that has ever infused or breathed in illicit medicines.
Any individual that has unusual liver function examination results with no recognized reason.
Babies born to mommies with liver disease C.
Health care and emergency situation workers who have actually been subjected to blood or unintentional needle sticks.
Individuals with hemophilia who were treated with clotting variables before 1987.
People that have undergone long-term hemodialysis treatments.
Individuals who received blood transfusions or organ transplants before 1992.
Sexual partners of any person diagnosed with hepatitis C infection.
People with HIV infection.
Anybody birthed from 1945 to 1965.
Any person that has remained in jail.

Other blood examinations.

If a preliminary blood test reveals that you have hepatitis C, extra blood examinations will:.

Procedure the amount of the hepatitis C virus in your blood (viral load).
Recognize the genotype of the virus.

Examinations for liver damage.

Physicians usually use one or more of the following tests to assess liver damage in chronic liver disease C.

Magnetic resonance elastography (MRE). A noninvasive option to a liver biopsy (see listed below), MRE combines magnetic vibration imaging innovation with patterns formed by sound waves bouncing off the liver to produce an aesthetic map revealing slopes of stiffness throughout the liver. Rigid liver cells shows the presence of scarring of the liver (fibrosis) as an outcome of chronic liver disease C.
Short-term elastography. One more noninvasive test, transient elastography is a type of ultrasound that transmits vibrations into the liver and also gauges the speed of their dispersal via liver cells to approximate its rigidity.
Liver biopsy. Commonly done using ultrasound support, this test entails inserting a thin needle through the stomach wall surface to remove a little example of liver cells for lab screening.
Blood tests. A series of blood examinations can show the extent of fibrosis in your liver.

Transient elastography treatment Short-term elastography.

A member of the treatment group executes transient elastography– a pain-free choice to liver biopsy– to assess liver damage.
Much more Details.

Hepatitis C care at Mayo Clinic.
Liver biopsy.

Treatment.
Antiviral medications.

Hepatitis C infection is treated with antiviral medicines planned to clear the virus from your body. The objective of treatment is to have no hepatitis C infection identified in your body at least 12 weeks after you full treatment.

Researchers have just recently made considerable advancements in treatment for hepatitis C making use of new, “direct-acting” antiviral medications, occasionally in mix with existing ones. Consequently, individuals experience better results, fewer side effects as well as much shorter treatment times– some as brief as eight weeks. The choice of drugs as well as size of treatment rely on the hepatitis C genotype, presence of existing liver damage, other medical problems as well as prior treatments.

As a result of the pace of research, recommendations for medications as well as treatment programs are changing rapidly. It is therefore best to discuss your treatment choices with a professional.

Throughout treatment your treatment group will certainly check your response to drugs.
Liver hair transplant.

Liver transplantation may be an option if you have developed major issues from chronic hepatitis C infection. Throughout liver hair transplant, the specialist removes your broken liver and changes it with a healthy and balanced liver. The majority of hair transplanted livers come from departed donors, though a handful originated from living contributors who give away a section of their livers.

A liver transplant alone does not treat hepatitis C The infection is most likely to return, calling for treatment with antiviral medicine to prevent damage to the transplanted liver. Numerous researches have shown that brand-new, direct-acting antiviral medicine regimens work at healing post-transplant hepatitis C. At the exact same time, treatment with direct-acting antivirals can be attained in suitably picked patients before liver hair transplant.
Vaccinations.

Although there is no vaccine for hepatitis C, your medical professional will likely suggest that you receive injections against the hepatitis An and also B viruses. These are separate viruses that also can create liver damages as well as complicate the course of chronic hepatitis C.

A noninvasive option to a liver biopsy (see listed below), MRE combines magnetic resonance imaging technology with patterns formed by sound waves bouncing off the liver to create a visual map showing gradients of stiffness throughout the liver. Stiff liver tissue indicates the presence of scarring of the liver (fibrosis) as a result of chronic hepatitis C.
Transient elastography. Another noninvasive test, transient elastography is a type of ultrasound that transmits vibrations into the liver and measures the speed of their dispersal through liver tissue to estimate its stiffness.
During liver transplantation, the surgeon removes your damaged liver and replaces it with a healthy liver. Most transplanted livers come from deceased donors, though a small number come from living donors who donate a portion of their livers.

General Information Regarding Adult Acute Myeloid Leukemia

Bottom line

Grown-up intense myeloid leukemia (AML) is a kind of cancer cells in which the bone marrow makes unusual myeloblasts (a type of leukocyte), red cell, or platelets.
Leukemia might impact red blood cells, white blood cells, as well as platelets.
There are different subtypes of AML.
Cigarette smoking, previous chemotherapy therapy, and also exposure to radiation might influence the threat of adult AML.
Signs and symptoms of grown-up AML include high temperature, feeling tired, and simple discoloration or blood loss.
Examinations that analyze the blood and also bone marrow are made use of to find (find) as well as identify grown-up AML.
Specific factors impact prognosis (opportunity of recuperation) and also therapy alternatives.

Grown-up acute myeloid leukemia (AML) is a type of cancer in which the bone marrow makes irregular myeloblasts (a kind of leukocyte), red blood cells, or platelets.

Grown-up intense myeloid leukemia (AML) is a cancer of the blood and also bone marrow. If it is not dealt with, this type of cancer cells typically gets worse promptly. It is the most typical type of severe leukemia in grownups. AML is also called intense myelogenous leukemia, acute myeloblastic leukemia, acute granulocytic leukemia, and severe nonlymphocytic leukemia.
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Anatomy of the bone; illustration reveals squishy bone, red marrow, and also yellow marrow. A random sample of the bone reveals small bone and also blood vessels in the bone marrow. Also revealed are red blood cells, leukocyte, platelets, as well as a blood stem cell.
Anatomy of the bone. The bone is comprised of portable bone, squishy bone, and bone marrow. Portable bone comprises the external layer of the bone. Mushy bone is found mostly at the ends of bones and includes red marrow. Bone marrow is found in the center of many bones as well as has several capillary. There are two sorts of bone marrow: yellow and red. Red marrow contains blood stem cells that can end up being red blood cells, leukocyte, or platelets. Yellow marrow is made primarily of fat.
Leukemia may influence red blood cells, white blood cells, and also platelets.

Typically, the bone marrow makes blood stem cells (premature cells) that end up being mature blood cells in time. A blood stem cell may come to be a myeloid stem cell or a lymphoid stem cell. A lymphoid stem cell becomes a white blood cell.

A myeloid stem cell becomes one of three sorts of fully grown blood cells:

Red blood cells that bring oxygen as well as various other substances to all tissues of the body.
White blood cells that deal with infection and illness.
Platelets that develop embolism to stop bleeding.

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Blood cell development; drawing reveals the actions a blood stem cell experiences to become a red cell, platelet, or leukocyte. Drawing shows a myeloid stem cell coming to be a red blood cell, platelet, or myeloblast, which after that comes to be a leukocyte. Drawing additionally reveals a lymphoid stem cell ending up being a lymphoblast and then among a number of various types of white blood cells.
Blood cell growth. A blood stem cell experiences numerous steps to end up being a red blood cell, platelet, or white blood cell.

In AML, the myeloid stem cells typically come to be a type of premature white blood cell called myeloblasts (or myeloid blasts). The myeloblasts in AML are unusual and do not come to be healthy and balanced white blood cells. Sometimes in AML, too many stem cells end up being irregular red cell or platelets. These unusual white blood cells, red blood cells, or platelets are additionally called leukemia cells or blasts. Leukemia cells can develop in the bone marrow and blood so there is much less area for healthy and balanced white blood cells, red blood cells, as well as platelets. When this occurs, infection, anemia, or simple bleeding might occur. The leukemia cells can spread outside the blood to various other parts of the body, including the main nerves (brain and spine), skin, and periodontals.

This recap is about grown-up AML. See the complying with PDQ recaps for details about various other kinds of leukemia:

Childhood Intense Myeloid Leukemia/Other Myeloid Malignancies Treatment
Persistent Myelogenous Leukemia Treatment
Adult Intense Lymphoblastic Leukemia Treatment
Childhood Years Severe Lymphoblastic Leukemia Treatment
Chronic Lymphocytic Leukemia Therapy
Unshaven Cell Leukemia Therapy

There are different subtypes of AML.

A lot of AML subtypes are based on exactly how mature (developed) the cancer cells go to the moment of diagnosis as well as exactly how different they are from regular cells.

Acute promyelocytic leukemia (APL) is a subtype of AML that takes place when parts of two genes stick. APL normally takes place in middle-aged grownups. Indicators of APL might consist of both blood loss as well as forming blood clots.
Cigarette smoking, previous chemotherapy therapy, and also exposure to radiation might influence the risk of adult AML.

Anything that boosts your risk of obtaining an illness is called a threat element. Having a risk factor does not indicate that you will obtain cancer cells; not having threat aspects doesn’t suggest that you will not obtain cancer. Talk with your physician if you believe you may go to danger. Possible threat factors for AML include the following:

Being man.
Cigarette smoking, especially after age 60.
Having had treatment with chemotherapy or radiation therapy in the past.
Having had therapy for youth intense lymphoblastic leukemia (ALL) in the past.
Being subjected to radiation from an atomic bomb or to the chemical benzene.
Having a background of a blood problem such as myelodysplastic syndrome.

Symptoms and signs of grown-up AML consist of high temperature, feeling tired, and also simple bruising or bleeding.

The early symptoms and signs of AML might resemble those caused by the flu or other typical conditions. Talk to your medical professional if you have any one of the following:

Fever.
Shortness of breath.
Easy bleeding or bruising.
Petechiae (flat, identify places under the skin brought on by bleeding).
Weakness or sensation tired.
Weight loss or anorexia nervosa.

Examinations that analyze the blood as well as bone marrow are utilized to discover (find) and detect grown-up AML.

The following procedures and also examinations might be utilized:

Physical examination and history: An exam of the body to check general indications of health and wellness, including looking for indications of condition, such as lumps or anything else that appears uncommon. A history of the person’s health and wellness routines and past health problems and also therapies will also be taken.
Complete blood count (CBC): A treatment in which an example of blood is attracted and checked for the following:
The number of red cell, white blood cells, and also platelets.
The amount of hemoglobin (the protein that lugs oxygen) at a loss blood cells.
The part of the example made up of red cell.
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Complete blood count (CBC); left panel programs blood being drawn from a blood vessel on the inside of the elbow joint utilizing a tube attached to a syringe; right panel shows a lab test tube with blood cells divided into layers: plasma, leukocyte, platelets, and also red cell.
Complete blood count (CBC). Blood is accumulated by putting a needle right into a blood vessel and also permitting the blood to flow into a tube. The blood sample is sent to the research laboratory and the red blood cells, white blood cells, and platelets are counted. The CBC is utilized to evaluate for, identify, as well as check many different conditions.
Peripheral blood smear: A procedure in which a sample of blood is looked for blast cells, the number as well as type of white blood cells, the variety of platelets, and modifications in the form of blood cells.
Bone marrow ambition as well as biopsy: The removal of bone marrow, blood, and also a tiny item of bone by putting a hollow needle right into the hipbone or breastbone. A pathologist views the bone marrow, blood, and also bone under a microscopic lense to look for signs of cancer cells.
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Bone marrow ambition and biopsy; illustration shows a patient lying face down on a table and also a bone marrow needle being inserted right into the hip bone. Inset reveals the bone marrow needle being placed through the skin into the bone marrow of the hip bone.
Bone marrow goal as well as biopsy. After a tiny area of skin is numbed, a bone marrow needle is inserted into the patient’s hip bone. Examples of blood, bone, and bone marrow are eliminated for assessment under a microscopic lense.
Cytogenetic evaluation: A lab test in which the cells in an example of blood or bone marrow are viewed under a microscopic lense to look for particular changes in the chromosomes. Other tests, such as fluorescence in situ hybridization (FISH), may also be done to search for particular changes in the chromosomes.
Immunophenotyping: A process made use of to determine cells, based on the types of antigens or pens on the surface area of the cell. A chemical may cause a color change in one type of leukemia cell but not in another type of leukemia cell.
Reverse transcription– polymerase chain reaction examination (RT– PCR): A laboratory examination in which cells in a sample of cells are researched utilizing chemicals to search for specific modifications in the structure or function of genes. This test is used to identify certain kinds of AML consisting of severe promyelocytic leukemia (APL).

Particular factors affect prognosis (opportunity of recuperation) as well as therapy options.

The prognosis (possibility of recuperation) as well as therapy choices depend upon:

The age of the individual.
The subtype of AML.
Whether the person received chemotherapy in the past to treat a various cancer cells.
Whether there is a background of a blood disorder such as myelodysplastic syndrome.
Whether the cancer cells has infected the central nervous system.
Whether the cancer has been dealt with before or recurred (return).

It is necessary that acute leukemia be treated right now.
Phases of Grownup Severe Myeloid Leukemia
Key Points

As soon as adult severe myeloid leukemia (AML) has actually been identified, tests are done to discover if the cancer cells has spread to various other parts of the body.
There is no common hosting system for adult AML.

When adult severe myeloid leukemia (AML) has been detected, tests are done to discover if the cancer cells has actually spread to various other parts of the body.

The level or spread of cancer is generally called stages. In adult intense myeloid leukemia (AML), the subtype of AML and whether the leukemia has actually spread outside the blood as well as bone marrow are utilized as opposed to the stage to plan treatment. The following examinations as well as procedures might be utilized to figure out if the leukemia has actually spread out:

Lumbar leak: A procedure used to accumulate an example of cerebrospinal fluid (CSF) from the spinal column. This is done by putting a needle in between 2 bones in the spine and also right into the CSF around the spine and eliminating a sample of the fluid. The example of CSF is checked under a microscopic lense for indications that leukemia cells have actually infected the brain and also spine. This procedure is likewise called an LP or spinal faucet.
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Back puncture; drawing shows a person hing on a curled placement on a table as well as a back needle (a long, thin needle) being placed into the lower back. Inset shows a close-up of the back needle put into the cerebrospinal fluid (CSF) in the lower part of the spine.
An individual exists in a crinkled position on a table. After a small area on the lower back is numbed, a back needle (a long, slim needle) is put into the lower component of the spine column to eliminate cerebrospinal fluid (CSF, revealed in blue).
CT scan (CAT check): A treatment that makes a series of thorough images of the abdominal area, taken from various angles. A dye might be injected right into a vein or ingested to assist the cells or body organs reveal up extra plainly.

There is no typical staging system for grown-up AML

The illness is described as neglected, in remission, or recurrent.

Neglected adult AML.

In without treatment adult AML, the disease is newly identified. It has actually not been dealt with other than to ease symptoms and also indications such as bleeding, high temperature, or discomfort, and the following hold true:

The complete blood count is unusual.
A minimum of 20% of the cells in the bone marrow are blasts (leukemia cells).
There are signs or signs of leukemia.

Adult AML in remission

In adult AML in remission, the disease has actually been dealt with as well as the complying with hold true:

The complete blood count is typical.
Less than 5% of the cells in the bone marrow are blasts (leukemia cells).
There are no indications or signs and symptoms of leukemia in the mind as well as spinal cord or somewhere else in the body.

Persistent Adult AML

Persistent AML is cancer cells that has actually repeated (come back) after it has actually been dealt with. The AML may come back in the blood or bone marrow.
Treatment Choice Summary
Key Points

There are different sorts of therapy for clients with grown-up severe myeloid leukemia.
The therapy of grown-up AML normally has 2 stages.
4 sorts of typical therapy are made use of:
Radiation treatment
Radiation therapy
Chemotherapy with stem cell transplant
Other medicine treatment
New sorts of treatment are being evaluated in professional tests.
Targeted therapy
Therapy for adult intense myeloid leukemia might cause side effects.
Clients may want to think about taking part in a clinical test.
People can go into medical tests before, throughout, or after beginning their cancer cells treatment.
Follow-up tests might be needed.

There are different sorts of therapy for people with grown-up acute myeloid leukemia.

Different kinds of treatment are readily available for clients with grown-up acute myeloid leukemia (AML). Some therapies are common (the presently utilized treatment), as well as some are being evaluated in medical trials. A therapy clinical test is a research study meant to assist get or improve current treatments information on new treatments for people with cancer. When professional tests reveal that a new treatment is far better than the basic treatment, the new treatment might end up being the standard treatment. Patients might wish to think about taking part in a clinical trial. Some clinical trials are open just to clients who have actually not begun treatment.
The therapy of adult AML usually has 2 stages.

The 2 therapy phases of grown-up AML are:

Remission induction therapy: This is the very first stage of treatment. The goal is to kill the leukemia cells in the blood and bone marrow. This places the leukemia into remission.
Post-remission treatment: This is the second phase of therapy. It starts after the leukemia remains in remission. The goal of post-remission treatment is to eliminate any type of continuing to be leukemia cells that may not be energetic but can start to trigger a relapse as well as regrow. This phase is additionally called remission extension treatment.

Four sorts of standard treatment are made use of:
Chemotherapy

Chemotherapy is a cancer treatment that makes use of medications to quit the growth of cancer cells, either by eliminating the cells or by quiting them from dividing. When chemotherapy is taken by mouth or injected into a capillary or muscle, the drugs go into the blood stream and can get to cancer cells throughout the body (systemic chemotherapy).

The way the chemotherapy is offered depends upon the subtype of AML being treated and also whether leukemia cells have actually infected the mind as well as spinal cord.
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Intrathecal chemotherapy; illustration reveals the cerebrospinal liquid (CSF) in the mind as well as spinal cord, as well as an Ommaya storage tank (a dome-shaped container that is placed under the scalp throughout surgical procedure; it holds the medications as they stream with a tiny tube into the brain). Leading area reveals a syringe and also needle injecting anticancer medicines into the Ommaya storage tank. Base area reveals a syringe as well as needle infusing anticancer medications straight into the cerebrospinal liquid in the lower part of the spinal column.
Intrathecal chemotherapy. One means, shown in the top part of the number, is to inject the medicines into an Ommaya reservoir (a dome-shaped container that is placed under the scalp throughout surgery; it holds the medications as they flow with a small tube right into the mind).

See Drugs Authorized for Severe Myeloid Leukemia for additional information.
Radiation treatment

Radiation treatment is a cancer cells therapy that uses high-energy x-rays or other sorts of radiation to eliminate cancer cells or maintain them from expanding. There are two types of radiation treatment:

External radiation therapy utilizes an equipment outside the body to send out radiation toward the cancer.
Inner radiation treatment makes use of a contaminated material sealed in needles, seeds, cords, or catheters that are placed straight right into or near the cancer cells.

The way the radiation therapy is provided depends on the type of cancer cells being treated as well as whether leukemia cells have infected the brain and also spine. Exterior radiation treatment is made use of to deal with grown-up AML.
Radiation treatment with stem cell transplant

Healthy cells, consisting of blood-forming cells, are also damaged by the cancer cells therapy. Stem cells (premature blood cells) are removed from the blood or bone marrow of the individual or a contributor and also are frozen and saved. These reinfused stem cells expand into (and bring back) the body’s blood cells.
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Stem cell transplant; (Panel 1): Drawing of stem cells being gotten rid of from a client or contributor. Blood is accumulated from a vein in the arm and moves with a device that gets rid of the stem cells; the staying blood is returned to a vein in the other arm. (Panel 2): Illustration of a healthcare supplier giving an individual therapy to kill blood-forming cells. Chemotherapy is offered to the patient with a catheter in the breast. (Panel 3): Illustration of stem cells being provided to the person via a catheter in the upper body.
Stem cell transplant. (Action 1): Blood is drawn from a blood vessel in the arm of the contributor. The individual or one more individual may be the donor. The blood streams through a machine that gets rid of the stem cells. The blood is returned to the contributor via a vein in the other arm. (Step 2): The patient receives radiation treatment to kill blood-forming cells. The individual might obtain radiation treatment (disappointed). (Step 3): The patient receives stem cells via a catheter placed into a blood vessel in the upper body.
Various other medication treatment

Arsenic trioxide and all-trans retinoic acid (ATRA) are anticancer drugs that eliminate leukemia cells, quit the leukemia cells from dividing, or assist the leukemia cells develop into leukocyte. These medicines are used in the treatment of a subtype of AML called intense promyelocytic leukemia.

See Drugs Accepted for Intense Myeloid Leukemia for more details.
Brand-new sorts of therapy are being tested in professional trials.

This recap section defines treatments that are being examined in scientific tests. It may not mention every new therapy being researched. Information regarding scientific tests is available from the NCI web site.
Targeted therapy

Targeted therapy is a sort of treatment that utilizes medicines or other materials to determine as well as attack certain cancer cells without damaging typical cells. Monoclonal antibody treatment is one sort of targeted therapy being researched in the treatment of adult AML.

Monoclonal antibody therapy is a cancer cells treatment that utilizes antibodies made in the laboratory from a single kind of immune system cell. These antibodies can identify materials on cancer cells or normal materials that might assist cancer cells expand.
Therapy for adult severe myeloid leukemia might trigger side effects.

For info regarding side effects caused by treatment for cancer cells, see our Side Consequences web page.
Individuals might want to think of taking part in a clinical test.

For some patients, taking part in a clinical test might be the very best treatment selection. Professional tests belong to the cancer research study process. Medical trials are done to learn if new cancer therapies are risk-free and effective or better than the typical treatment.

A lot of today’s basic treatments for cancer cells are based on earlier professional trials. Patients that take part in a clinical test might get the basic treatment or be amongst the first to obtain a brand-new treatment.

Patients that take part in professional trials also help enhance the means cancer will certainly be treated in the future. Also when clinical trials do not result in efficient new therapies, they typically address vital concerns and also aid move study onward.
People can go into medical tests prior to, during, or after beginning their cancer treatment.

Some professional tests just consist of people who have actually not yet received therapy. Other trials test treatments for people whose cancer has not gotten better. There are likewise medical trials that evaluate new ways to stop cancer cells from reoccuring (returning) or minimize the side effects of cancer treatment.

Professional trials are happening in lots of parts of the nation. Info concerning medical trials supported by NCI can be found on NCI’s clinical trials search website. Scientific tests sustained by other companies can be found on the ClinicalTrials.gov website.
Follow-up tests may be required.

Shown are red blood cells, white blood cells, platelets, and also a blood stem cell.
Red marrow consists of blood stem cells that can end up being red blood cells, white blood cells, or platelets. Blood cell advancement; drawing shows the actions a blood stem cell goes through to come to be a red blood cell, platelet, or white blood cell. These irregular white blood cells, red blood cells, or platelets are also called leukemia cells or blasts. Leukemia cells can construct up in the bone marrow and also blood so there is much less area for healthy white blood cells, red blood cells, as well as platelets.

Hepatitis C Treatment is Empowering

Hepatitis C Treatment

If you believe you are at risk of having Hepatitis C, speak with your present healthcare provider regarding getting checked and receiving hepatitis C treatment. You may desire to see an expert once you have actually been detected with Hepatitis C infection. Specialists that work with people with Hepatitis C include the adhering to doctor:

A bulk of individuals with an acute Hepatitis C infection usually do not know they have the virus and also consequently do not obtain dealt with. Nonetheless, if a person realizes that they may have been subjected to the infection– like a healthcare employee that obtains a needle stick– an intense Hepatitis C infection can be determined early as well as drug may be recommended.

Chronic (long term) Hepatitis C.

Acute (short term) Hepatitis C.

hepatitis c treatment
hepatitis c treatment

Physicians that focus on liver conditions (hepatologist).
Medical professionals who focus on belly as well as intestinal tract conditions (gastroenterologist).
Physicians that specialize in contagious illness.
Nurse practitioners whose technique concentrates on individuals with liver diseases.

Treatment for Hepatitis C depends upon numerous elements, including:.

Nurse practitioners are signed up nurses that are prepared– via advanced education and learning as well as professional training– to assume several of the duties formerly thought just by doctors. They work in a treatment group, and also can supply a vast array of healthcare services, including the medical diagnosis as well as monitoring of common, in addition to complicated medial conditions.

Some points your Hepatitis C carrier will certainly need to know when discussing your eligibility for treatment, in addition to choosing which treatment program is best for you, include the following:.

How much infection remains in your body (your viral loads).
The genotype or strain of Hepatitis C you have.
Such as cirrhosis if you have liver damage.
What other health conditions you have.
Your feedback to any previous therapies for Liver disease C.

Chronic Hepatitis C is defined by the visibility of the hepatitis C virus (HCV) for 6 months or longer. Many individuals already have chronic Hepatitis C when they’re first identified because they were unknowingly contaminated with the infection many years back. Your healthcare provider will certainly review you to establish just how much damages, or scarring, is present in your liver.

In the past, when treatment for Hepatitis C generally contained interferon as well as ribavirin, adverse effects averted numerous clients from being eligible. With the present accessibility of interferon-free treatment routines, several of these individuals can currently obtain treatment for their Hepatitis C infection.

If you have little to light scarring (very early phase fibrosis), you must still take into consideration Hepatitis C treatment to stay clear of the long-lasting problems of the disease, even though you might not be at danger for several years. Go over the risks and also benefits of seeking treatment with your healthcare carrier.

Physicians sometimes simply advise bed remainder, drinking lots of liquids, eating a healthy and balanced diet plan, and also preventing alcohol. You must see your physician frequently for follow-up blood examinations to see to it your body has actually fully recovered from the infection.

What medicines do you presently take?

As an example, people taking amiodarone (brand: Cordarone, Nexterone, Pacerone) should not take Sovaldi or Harvoni due to major risks of a sluggish heart price; deaths have actually been reported. Individuals taking amiodarone would certainly require to take some other Hepatitis C treatment.

Some medicines interact with Hepatitis C medications, which can affect the degree of either one– meaning that the degree of the Hepatitis C medicine or your other medicine may come to be also reduced or too high. There can be dangers of poisoning if too high, or the drug may be much less reliable if too reduced. If readily available, your Hepatitis C service provider will certainly choose a treatment alternative without interactions. Otherwise available, he or she can speak with your various other healthcare providers regarding the possibility of changing your present medications prior to Hepatitis C treatment begins.

Do you have kidney disease?

If you have kidney condition you need to talk with your medical professional about which treatment alternatives might be ideal for you. For example, Sovaldi as well as Harvoni are not recommended for individuals who have more advanced kidney disease. Furthermore, individuals with advanced kidney condition or those on dialysis who take ribavirin– which is gotten rid of by the kidneys– should take reduced doses and be very closely checked. Some companies do not advise ribavirin for these individuals.

Do you have any type of medical problems that create anemia (reduced red cell matter)?

Treatment programs that include ribavirin may not be advised for some people that have a problem that causes anemia. Ribavirin creates anemia as well as people with an existing condition that results in anemia might not be able to endure a more decrease in their red cell.

Are you pregnant?

There are several things that are taken into consideration when obtaining reviewed for a liver transplant. You need to be healthy and balanced enough to tolerate the surgery and also recuperation period– which is long– as well as have a support system in place that can help you via the procedure. If your liver disease is severe enough that referral for a transplant is appropriate, your doctor will determine.

Over time, chronic Hepatitis C can lead to severe liver problems– including cirrhosis and liver cancer– resulting in decreased liver function and ultimately, liver failure. Chronic Hepatitis C is the most frequent cause of liver transplantation in the United States.

Antiviral medications may not be advised if you are expectant, since these medications can cause birth defects in infants.
Liver Transplant.

Over time, chronic Hepatitis C can lead to severe liver problems– including cirrhosis and liver cancer– resulting in decreased liver function and ultimately, liver failure. Chronic Hepatitis C is the most frequent cause of liver transplantation in the United States.

Chronic Hepatitis C is defined by the presence of the hepatitis C virus (HCV) for 6 months or longer. Some medicines interact with Hepatitis C medications, which can affect the level of either one– meaning that the level of the Hepatitis C medicine or your other medicine may become too high or too low. If not available, he or she can talk to your other healthcare providers about the possibility of changing your current medicines before Hepatitis C treatment begins.

Developments in the medical and surgical management of liver transplant have actually caused boosted end results, however, people with Hepatitis C generally do not do also considering that the infection generally contaminates the donor liver. Most people that get a liver transplant for Hepatitis C endure at least five years after their transplant.

Chronic (long term) Hepatitis C.

A liver transplant changes a problems liver with a healthy one from someone else. A lot of the time, a liver is donated from someone who has died. In rare situations, a living individual gives away a portion of their liver. Livers should be matched for blood type and body dimension.

Hepatitis C infection is treated with antiviral medications meant to get rid of the infection from your body. Your medical professional may suggest one drug or a combination of two to three medications to be taken for 12– 24 weeks or longer. Blood tests and physician check outs are needed throughout this time around so that your reaction to treatment can be thoroughly kept track of as well as assessed.

Unlike Liver disease An as well as Liver Disease B, an injection for Hepatitis C is not offered.

The function of using medicines Hepatitis C treatment is to:

Clear the Hepatitis C infection from your blood stream
Reduce development of inflammation and scarring of your liver
Decrease the possibilities of creating cirrhosis as well as liver cancer cells

One of the most important factors affecting your hepatitis C treatment outcomes are:

Your Hepatitis C genotype
Whether you have cirrhosis (extreme scarring of the liver).
Taking medicines as prescribed; not missing out on dosages.

Sunny Pharma helps patients get hepatitis C treatment and get cured.  All direct acting antivirals are available like generic Harvoni, generic Sovaldi, generic Epclusa, generic Vosevi, generic Daklinza and others.  Treatments for pan genotypes of hep c include velpatasvir sofosbuvir.

Sofosbuvir Price in India Makes Me Happy

Sofosbuvir Price in India Makes Me Happy

Medication Summary:

Sofosbuvir was an innovation brand-new drug for the treatment of people with persistent hepatitis C. Sofosbuvir has a variety of ideal properties, consisting of once daily dosing, no meal restrictions, few damaging impacts, marginal drug-drug communications, high genetic obstacle to resistance, and also reasonably great safety as well as efficiency in people with sophisticated liver illness.

 

Using sofosbuvir in mix with ribavirin was the first FDA-approved all oral treatment for hepatitis C. Of note, the task versus genotype 3 appears less than with genotype 2 as well as treatment of genotype 3 infection needs a much longer all-oral program of treatment than with genotype 2. Sofosbuvir is primarily made use of now in fixed-dose combinations.  Sofosbuvir price is very affordable in India compared to the US.

Mechanism of Action of Sofosbuvir

Sofosbuvir is a nucleotide analog prevention of hepatitis C infection NS5B polymerase– the crucial enzyme moderating HCV RNA replication. Sofosbuvir is a prodrug and after ingestion it is swiftly transformed to GS-331007, the predominant distributing drug that accounts for higher than 90% of the systemically energetic medication. The energetic substance (GS-461203) does not hinder host DNA polymerases, RNA polymerases, or mitochondrial RNA polymerase.

American Manufacturer of Sofosbuvir | Indian Manufacturer

Sofosbuvir is manufactured as Sovaldi (soh-VAHL-dee) by Gilead Sciences (Number 1) and also (Number 2). The drug sofosbuvir was previously called GS-7977 and also was originally developed by Pharmasset as compound PSI-7977.  Indian authorized generics of sofosbuvir are manufactured by Natco Pharma and Gilead Sciences India.

Access to Hepatitis C Treatment

Accordingly, the cost for the sofosbuvir element in a 12-week treatment training course is $84,000 (and also the complete program cost is depends on the other drugs used in combination with sofosbuvir). Gilead Sciences has an active sofosbuvir person support program for qualified people with hepatitis C who do not have insurance coverage and are not covered by Medicaid or Medicare.

Sofosbuvir Side Effects

Sofosbuvir is normally well-tolerated. The most common adverse results observed with sofosbuvir, when used in mix with ribavirin, have been exhaustion as well as migraine. Sofosbuvir is pregnancy classification B.

Donna’s Hep C Survivor Story 3

Donna’s Hep C Survivor Story 3

Donna’s Story
By Donna

My name is Donna and in 1989 while giving birth to my twin sons by c-section i had complications and required a blood transfusion. That’s how the docs think i got the hep c virus due to the high viral load, didn’t look like tattoo or needle stick or etc……anyway I was diagnosed with cervical and uterine cancer in 1994 and during the pre-surgical testing they discovered I had hepatitis C.

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I lived through the cancer, but come 1999 upper quadrant pain and fatigue came along. I had testing and liver biopsy, and my liver was pretty eaten up. When I found out through Johns Hopkins Hospital that a living donor was possible, my sister stepped up and tested compatible to be a donor all the way until 2 days before surgery. They had taken another look at her cat scan and noticed that right where they would have to separate her liver there was an artery and the surgery would be too risky. This was a hard blow as I was getting considerably more ill, but nothing was worth risking my sister’s life.

One of my twin son’s had a husband and wife mentor team (big brother and big sister) the husband Steve McCann decided he wanted to be the donor for me. I couldn’t believe the brave act he was prepared to do for me especially considering that he and his wife had a 17 month old boy, their first child. Steve went through all the neccessary testing and on 12/10/01 we had a successful 21 hour surgery. It has been 6 1/2 months and I am doing quite well and so is he.

Now we are doing fundraising due to the fact that my work 3 months prior to the transplant called me into the office and told me I was suspended without pay and told to leave the office because they felt I was contagious and the other employees felt threatened. I had been the medical billing supervisor for 5 years, and was a very faithful hardworking employee despite the hepatitis C. It was a pain management practice, so the doctor I worked for was also a treating physician of mine (supposedly) I had a lot of pain from my spleen and he could have done a procedure to block the pain but instead he treated me with narcotics, which eventually lead to a high tolerance and addiction.

The doctor I worked for had used my confidential information against me and my chart became public knowledge for all of the staff to see. They knew I needed a transplant but I never told them why. Apparently they must have helped themselves to my chart. I could not believe that a medical office was throwing me out because of hepatitis C, as we had many patients with hep C as well as HIV.

Anyway I now have an attorney and have filed a complaint with the Department of Labor, but the staff and management from my former employer is lying. They’re saying they’ve seen me bleed and I was a threat to them. I have been so degraded and so back stabbed that I am devastated. I’ve written to the press, because I want this story told. I want people to know what happened to me so that no other employer ever does this to another employee again, but I just can’t get the story out. I see some pretty unimportant issues that get attention on TV and the newspaper but few like this one. I need to let the public know that employers can not do this. This is not acceptable and the public also needs to know exactly how the virus is transmitted so that no one else has to go through what I went through.

I told myself I will win and will. Its just a matter of time. Because I was not employed and just got out of a transplant surgery, I had no insurance either. During all of this my sons hid the fact that they also had hep C. They don’t know if it was me or it was from tattoos. My younger of the twin is bit of computer whiz. He got online and started doing research for type of treatment is needed for hep C genotype 1, he found out that the Harvoni drug cost $94,000 in the US. He even had a friend in California go down to a pharmacy in Mexico, and the price of Harvoni in Mexico was almost the same about $80,000. He kept searching and then he got on a forum for those with hep C and found a gal named Melissa McKnight who had gone through similar situation with her father. She ran a non profit and a hepatitis C pharmacy called Sunny Pharma.

Melissa referred my younger twin to Kumar to have hep C treatment sent to us in Kansas City. We were little worried because the meds were coming from India, but Kumar said we will give you folks a money back guarantee. I wasn’t really worried about the guarantee, I didn’t know if the meds were good or possibly even dangerous. Well we all took the plunge and two weeks in to it, we started feeling much better than before.

My eldest twin, had his viral loads checked and he was already clear. We called up Sunny Pharma and Kumar said complete the treatment, go the full length of 84 days. Its not worth it to take the risk.

This gave me even more confidence regarding my hep c virus. Well, after 12 weeks, my sons and I got tested. It took almost a week and half to get the results back because of Christmas. Well, we got them back, we no longer had hepatitis C. The hep C treatment cost from Sunny Pharma was less than $3,000 for all three of us.

My youngest son, reached out Melissa and gave her a big thanks. She was so happy, genuinely happy. I called up Kumar at Sunny Pharma and he was extremely happy but was concerned and wanted our family to get tested again in another 6 months. Kumar reminds me of a typical Indian man that is over protective and cautious. Great guy and very open heart. God bless him and Melissa for helping us get through this.

Eesamoosa’s Hep C Survivor Story 4

Melinda’s Hep C Survivor Story 1

Melinda’s Hep C Survivor Story 1
By Melinda

I am going to fight a good fight though and do all I can to fight this hep c virus. I suffer bouts of depression though and hope it will not get me down.

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I had my liver biopsy and was very sad when I got the results. I have finally gotten my scripts for Harvoni (ledipasvir sofosbuvir) but I can’t afford it. I got ta hold of Sunny Pharma, Kumar sent me the meds for $800. I want to go to work so bad but I get sick to often now to keep a job and it is not fair to my employer if I am sick all the time.

I had been having problems with my liver enzymes being elevated up to 169 for the alt’s and 122 for the ast’s. I suffer from chronic pain and fatigue. I had my liver biopsy and was very sad when I got the results.

But the doc said it wasn’t that bad and he gave me courage and I really appreciated that.  So many doctors don’t really care espcially when you get this horrific disease.  For the longest time I had no idea why I felt tired and had this foggy problem when it came to doing some basic chores and even writing checks out to bills.

I’m on my second week and this hep c med is really kicking in.  I feel so much better than I had for years, almost over a decade.  I just thought I was getting old but in reality it was the hep c virus doing the hurting all the time.  Some people have told me that they have literally been clinically depressed and put on lots of anti depressants because of hep c.  I never thought it could be this bad.

What’s worst is I have met so many people that have been denied for hep c treatment and I wish I could do something.  I have the fight in me to do that and I now know a good resource to get treatment to help so many.  No way most people cannot afford the generic Harvoni at $24,000.  My doctor recommended me to Kumar.  He’s been a little angel in my life after this hep C issue.

I’m cured now and Iam more than grateful to Soul of Healing and Sunny Pharma, for sending me generic Harvoni, Hepcinat LP. Thank you Kumar.

Melinda

Sharon’s Hep C Survivor Story 2

Eesamoosa’s Hep C Survivor Story 4

Eesamoosa’s Hep C Survivor Story (by Eesamoosa)

About ten years ago I accidentally found out that I had Hep C. I really did not know what that meant at the time. The years have passed by and I really hadn’t thought about it much. Within the past two years I have become self employed. Being self employed has its limitations. I no longer had an employer to provide me with health insurance. I found an insurance broker and he began the search for a company who could offer me coverage that I could afford. Of course when I filled the paperwork out I did not mention the Hep C because I have never felt bad or needed any help medically and there was the fact that I knew I would be refused by any insurance company if they were to discover my well kept secret. I have had my own personal health insurance now for about seven months. I went to see a specialist about some possible depression or menopause effects. I was not sure what I was going through and regular doctors are always willing to doll out the meds without really knowing what the problem is. I try to be careful with meds and the impact they can have on the liver. I confided in this psychiatrist that I had Hep C and to please not give me anything that would be hard on my liver. The insurance company got my records from her and discovered that I had Hep C as well as other personal facts that are extremely damaging. They have asked me to sign forms that give them access to other medical records. If I do not supply the signatures on the forms they have threatened to make me responsible for every medical bill I have acquired since I began seven months ago. I felt exposed and angry that my privacy was now public knowledge and I would probably not be able to get health insurance on my own again. I am thinking of the letter I will write in response but I feel hopeless. I have not been tested in the years that have passed, I only know that I don’t feel bad but it won’t matter to an insurance company. It will be interesting to see what happens next. I am approaching my 46th birthday and don’t know what I will do for health care. That was last month. Then I ran in to a friend, she confided in me that she had hep C. Her doctor informed her there is a cure for hepatitis C now. Insurance is picky about who it covers and who it doesn’t. I had mentioned that I have insurance but they’re being prickly at this time and I don’t know if I should tell them or not.

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I may have gotten hepatitis C when I lived in Nigeria

She said her doctor works with a lot of low income people and they don’t have insurance either but they got treatment. My friend, at this time got a little bit more closer to me and said, the doctor get his hep C treatment from India a non profit called Sunny Pharma. The cost is less than a $1000 and you will be cured. He guarantees it. This was a huge relief for me and I felt so much better after hearing all of this. Now, I don’t even care about my health insurance for the time being. So, I made an appointment to see him and he said some of the depression issues are due to the virus. So, be careful and get started on treatment right away. I did exactly that, I got what was called Velpanat, I guess its the generic version of Epclusa here in the US. Within 1 week, I started feeling better and my mood was more positive. I finished my 12 weeks course and I got tested and there was no viral load that could hurt me. I went to see my psychiatrist and told him that I do not have the hep C virus anymore and I’m cured. My insurance had me get tested for hep C and there was no viral load. They believed that the body had beat the virus, some 25% of the population beats the virus without any meds. Right now I have insurance and my solopreneur is doing ok, I just have to get out and start banging on doors. I feel a lot better these days than ever before. Thanks everyone for reading my story. It really helps to get information out regarding how you feel and what you’re going through so you’re not alone. https://ama-ssn.org/africa-nigeria-dont-have-a-chance-for-hep-c-treatment-5/

Hep C… Herpes and DAAs Story 6

Hep C… Herpes and DAAs

Here are a couple of  interesting emails I have received  from different folk infected with Herpes who have recently done Hepatitis C treatment with Sofosbuvir + Daclatasvir. The first one is from a guy who I sent Hep C medication to three years ago. Apart from the good news about clearing Hep C he also mentioned that the 24 week treatment with Sofosbuvir + Daclatasvir appears to have cleared herpes virus.

Dianne’s Story
(by Dianne)

I was 36 when I started Alpha interferon. I did the 6 million IU then 12 million. Liver enzymes always shot up after discontinuing. I then went on the Beta Inferon. After two months my periods stopped. I went to my GYN and my thyroid was out of whack they said from the interferon. My periods stopped shortly afterwards and I was in full peri-menopause. I now had complete ovarian failure. I no longer could conceive and I was put on Hormones for the menopausal symptoms. The women in my family all went into menopause in their 50s. I had planned on attempting pregnancy after all my treatment was over.

No doctors have acknowledged that ovarian failure was caused by my interferon treatments. However, in an older PDR (physicians desk reference) it says interferon is used for treatment of certain cancers and has been shown to cause sterility problems in women.

If they are going to push interferon treatments on women, they need to study this more. I was treated at a VA hospital. Most of the protocol studies are done on men. This is my warning to all women who may still be considering childbirth: Interferon may end your chance of having children.

Good news is I did get treated for hep C in 2014.  I was denied and I was able to afford hep C meds from a doctor that referred to me Sunny Pharma.  Check this out my treatment in the US cost $194,000 and I got my 24 weeks treatment for less than $2000.

This bogus healthcare system destroyed my chance of having children and on top of that they want to bankrupt me for hepc meds.  I am urging everyone do not even try to take interferon it will destroy your ovaries, get treated with the new sofosbuvir direct acting antivirals they work.

My husband and I adopted two children from India, a boy and a girl.  Brother and sister, absolute dolls, they’re only a year and 2 years old.  A blessing for us to do good and by helping those that can’t.  We want to give something back and those children chose us.

Mike’s Hepatitis C Survivor Story 8

Mike’s Hepatitis C Survivor Story 8

My name is Mike Childress. I am 48 years old. I am being treated by Dr. Steven Lacey from Digestive Disease Consultants in Grapevine, Texas. I was feeling extremely tired and run down. I had shortness of breath and decided an EKG and full check up was in order. I went to the family doctor in mid August 99. hepc drugs, hepatitis c treatment, generic daklinza, generic sofosbuvir, sofosbuvir price, ribavirin, hep c treatment cost, generic harvoni, generic eplcusa, velpanat, hepcinat lp, velasof, resof total, resof l, myhep lvir, myhep, myhep all, ledifos, hep c treatment cost in india, harvoni cost in india, harvoni price in india, epclusa price in india, epclusa cost in india, harvoni tablets price, epclusa tablets price

My Timeline with Hepatitis C

The last week of August I was in the Cincinnati airport waiting on a connecting flight to get to the Michigan NASCAR event when my cell phone rang. The nurse told me my ekg was fine but the test showed some liver abnormalities and to come in with my wife as soon as I returned. She also told me not to drink alcohol. I returned and was sent to the Hepatologist, did the biopsy and started the combo therapy resolved to give it a shot. I was an executive with The Studios at Las Colinas, an Independent Film Studio. So I told my owners and staff thinking after 20 years I could coast for 1. WRONG! Within a week I was told my job no longer required someone of my caliber and pay scale. But for a 50% reduction in base pay, no more bonus or commission, I could stay and do the same job while taking on other duties. Needless to say I am no longer employed by this fine CHRISTIAN company.

Hepatitis C Discrimination

There are many forms of discrimination in our world. I was the victim of greed discrimination. Mr. Chris Christian the owner did not want me if I had to do the hep C treatment and miss any time due to sickness or Dr. appointments. This made me bitter but I held my head high and marched out on a great career to do what was right for me and my family.  They cut me off from insurance because I was too high of a risk.  I know that’s not legal.  They did everything but fire me.  They wanted me OUT! My insurance no longer exists, I have a job (for now), I have hepatitis C, what the heck do I do.  Thank God my wife’s insurance covered me, but they denied treatment for Epclusa, the velpatasvir and sofosbuvir combination.  If I was a chemist, I would have made that and gave it to everyone for FREE.  In my dreams.  Dr. Lacey informed me about Soul of Healing, a non profit and Sunny Pharma for the generic Epclusa.  I didn’t care what it was, I wanted the cure and I want to be a productive family member again.  Look for another job after I’m done with the 12 weeks hep c treatment.

Gilead Generic Epclusa

I am now finishing my 12 weeks  of generic Epclusa treatment and it seems to have taken hold in me. Dr. Lacey said if I hadn’t started I would be looking pretty bad right now as my liver was the worst he had treated. My lab test now make him very happy and all I think about is feeling good again. I have had very acute side effects possibly due to the advanced damage and disease.  I am very happy and my family is happy. My advise is to follow your doctors order and do not fudge for any reason. I will miss the Daytona 500 this year, for the first time since 1990 even though I only have 2 week to go then. I will finish what I started, hopefully with a clean system and great hopes for all of our future. Thanks for reading. Mike Childress https://ama-ssn.org/valenes-hepatitis-c-survivor-story-9/

Facebook and Hepatitis C Support

Today our Hepatitis C Facebook group passed the milestone of gaining more than 2,000 members in less than 18 months of existence. It was a great moment for myself and all the other group members because the numbers are a reflection of what a helpful, sharing and caring online community Hepatitis C Treatment, Cure and Community has become. hep c treatment cost, generic harvoni, hepcinat lp, hepcinat, generic sovaldi, velpanat, generic epclusa, ledipasvir sofosbuvir, velpatasvir sofosbuvir, myhep lvir, ledifos, ledipasvir 90mg sofosbuvir 400mg, velpatasvir 100mg sofosbuvir 400mg, sofosbuvir price, vosevi, mavyret, hepc treatment, free hep c treatment, hep c drugs, hep c treatment cost in india, harvoni generic name, ledifos tablets, natdac, natco pharma products list, velpanat price, velpanat tablet price, velpanat natco price, myhep all, velasof, sovihep, resof total, sofosbuvir side effects sofosbuvir price india sofosbuvir synthesis daclatasvir, simeprevir, ledvir, sofosbuvir and daclatasvir, daclatasvir 60mg, michael sofia, epclusa interactions, harvoni side effects, resof, resof L One of the most important aspects of t Facebook group has been that people willingly share their experiences and knowledge with each other. T is very important because, whilst we are not medical people, we have that valuable asset of real life experience with Hepatitis C.  More than 70% of the group’s membership have gone through the shock of learning that they have Hep C and then the following process of learning what their treatment options are and then the final processes of  doing the treatment and being cured.

A Supportive Online Hep C Community: Sharing And Caring

To be able to share all these aspects of Hepatitis C with people who have just started down the path of treatment and cure is super valuable. Particularly as in many countries (even “First World” nations) many medical professionals have very limited practical knowledge about Hepatitis C. For example today I received an email from a guy in the USA with Hep C genotype 1a who was told by doctor that G1a was the most difficult genotype of Hep C to cure… Wrong, that honor goes to Genotype 3 (Sofosbuvir-Velpatasvir-Voxilaprevir).Genotype 1a was difficult to cure back six years ago before Harvoni. And I do not know how many emails I get from very upset people who have completed treatment and been told by their doctor that the treatment was unsuccessful, that they are still infected with Hepatitis C… T advice being based on a positive result from a Hep C antibody test. Wrong! Anyone successfully treated for Hep C will always be positive for Hep C antibodies. So, having around  2,000 people who have done Hep C treatment and are willing to share their knowledge and experiences with new members is just BRILLIANT!!!